Humana is the first major insurer to announce it will drop out of the Obamacare exchanges in 2018.
Last year, Humana announced that it would scale back participation from 15 states to 11, citing financial losses.
"All of these actions were taken with the expectation that the company's individual commercial business would stabilize to the point where the company could continue to participate in the program," Humana said.
"However, based on its initial analysis of data associated with the company's healthcare exchange membership following the 2017 open enrollment period, Humana is seeing further signs of an unbalanced risk pool," the company said. "Therefore, the company has decided that it cannot continue to offer this coverage for 2018."
The company serves roughly 150,000 individuals through the Obamacare exchanges.
President Trump commented on the announcement over Twitter, saying that Obamacare continues to fail and that he intends to repeal, replace, and save healthcare for all Americans.